The Usability principle states that the medical AI solutions should be usable, acceptable and deployable for the end-users in real-world practice, such as physicians, specialists, data managers and other end-users. To ensure their acceptance and adoption, the AI tools should facilitate the image analysis tasks, including the visualisation and interpretation of complex medical images, with increased productivity and satisfaction. It is important that the AI algorithms are developed while taking into account the human factors for each clinical task, by employing human-centred approaches with user engagement throughout the AI development process, including iterative usability testing. To ensure the deployability of medical AI tools, effectiveness must be estimated and integration into current clinical workflows must be demonstrated. To ensure the Usability of AI solutions in medicine and healthcare, we propose the following recommendations: